Project Description
Per- and poly-fluoroalkyl substances (PFAS), also known as 鈥渇orever chemicals鈥, are omnipresent environmental contaminants that are highly toxic to invertebrates, wildlife, and humans. These fluorinated aliphatic compounds have been used in a variety of industrial applications and consumer products since the early 1950s and are resistant to environmental degradation due to their strong carbon-fluorine bond. Worldwide and toxicologic studies investing PFAS have revealed that these chemicals cause developmental delays, endocrine disruption, reproductive harm, and immunological effects in vertebrates. PFAS primarily enter the environment through the discharge of contaminated wastewater from industrial facilities and from the use of aqueous fire-fighting foams. From there, PFAS enter aquatic ecosystems where they are readily absorbed by both vertebrates and invertebrates following oral exposure. The overall objective of this work is to determine the effect PFAS exposure has on the fitness and development of mosquitoes.